Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TTK |
Gene ID: | 7272 |
Uniprot ID: | TTK_HUMAN |
Immunogen Region: | 536-789 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 536-789 of human TTK (NP_003309.2). |
Immunogen Sequence: | SSKVFQVLNEKKQIYAIKYV NLEEADNQTLDSYRNEIAYL NKLQQHSDKIIRLYDYEITD QYIYMVMECGNIDLNSWLKK KKSIDPWERKSYWKNMLEAV HTIHQHGIVHSDLKPANFLI VDGMLKLIDFGIANQMQPDT TSVVKDSQVGTVNYMPPEAI KDMSSSRENGKSKSKISPKS DVWSLGCILYYMTYGKTPFQ QIINQISKLHAIIDPNHEIE FPDIPEKDLQDVLKCCLKR |
Tissue Specificity | Present in rapidly proliferating cell lines. |
Function | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. |
Protein Name | Dual Specificity Protein Kinase TtkPhosphotyrosine Picked Threonine-Protein KinasePyt |
Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Ttk antibodyAnti-Phosphotyrosine Picked Threonine-Protein Kinase antibodyAnti-Pyt antibodyAnti-TTK antibodyAnti-MPS1 antibodyAnti-MPS1L1 antibody |
Information sourced from Uniprot.org