Anti-TTF-1 antibody [IHC141] (STJA0042279)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
General Information
| Short Description | Rabbit monoclonal anti-TTF-1 for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC141 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Gene Symbol | NKX2-1 |
| Gene ID | 7080 |
| Uniprot ID | NKX21_HUMAN |
| Specificity | Tested and validated on lung adenocarcinoma tissue. |
Additional Info
| Tissue Specificity | Thyroid and lung. |
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1Homeobox Protein Nk-2 Homolog AThyroid Nuclear Factor 1Thyroid Transcription Factor 1Ttf-1Thyroid-Specific Enhancer-Binding ProteinT/Ebp |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibodyAnti-Homeobox Protein Nk-2 Homolog A antibodyAnti-Thyroid Nuclear Factor 1 antibodyAnti-Thyroid Transcription Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Thyroid-Specific Enhancer-Binding Protein antibodyAnti-T/Ebp antibodyAnti-NKX2-1 antibodyAnti-NKX2A antibodyAnti-TITF1 antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org