| Tissue Specificity | Thyroid and lung. |
| Post Translational Modifications | Phosphorylated on serine residues by STK3/MST2. |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. |
| Protein Name | Homeobox Protein Nkx-2.1Homeobox Protein Nk-2 Homolog AThyroid Nuclear Factor 1Thyroid Transcription Factor 1Ttf-1Thyroid-Specific Enhancer-Binding ProteinT/Ebp |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.1 antibodyAnti-Homeobox Protein Nk-2 Homolog A antibodyAnti-Thyroid Nuclear Factor 1 antibodyAnti-Thyroid Transcription Factor 1 antibodyAnti-Ttf-1 antibodyAnti-Thyroid-Specific Enhancer-Binding Protein antibodyAnti-T/Ebp antibodyAnti-NKX2-1 antibodyAnti-NKX2A antibodyAnti-TITF1 antibodyAnti-TTF1 antibody |
Information sourced from Uniprot.org
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