| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-TSPAN5/NET-4 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 35kDa band observed in Human, Mouse and Rat Brain lysates (calculated MW of 30.3kDa according to NP_005714.2). This molecular weight is routinely observed by other sources. Rec |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TSPAN5 |
| Gene ID: |
10098 |
| Uniprot ID: |
TSN5_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_005714.2 |
| Immunogen Sequence: |
SGKHYKGPEVSC |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration. |
| Protein Name | Tetraspanin-5Tspan-5Tetraspan Net-4Transmembrane 4 Superfamily Member 9 |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tetraspanin-5 antibodyAnti-Tspan-5 antibodyAnti-Tetraspan Net-4 antibodyAnti-Transmembrane 4 Superfamily Member 9 antibodyAnti-TSPAN5 antibodyAnti-TM4SF9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
