| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TSH (25-116) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen Region: |
25-116 |
| Immunogen: |
Recombinant Protein corresponding to a sequence within amino acids 25-116&21-138 of human Thyroid Stimulating Hormone (TSH) (NP_000726.1/NP_000540.2). |
| Immunogen Sequence: |
APDVQDCPECTLQENPFFSQ PGAPILQCMGCCFSRAYPTP LRSKKTMLVQKNVTSESTCC VAKSYNRVTVMGGFKVENHT ACHCSTCYYHKSGGGGSGGG GSGGGGSFCIPTEYTMHIER RECAYCLTINTTICAGYCMT RDINGKLFLPKYALSQDVCT YRDFIYRTVEIPGCPLHVAP YFSYPVALSCKCGKCNTDYS DCIHEAIKTNYCTKPQKSYL VGFSV |
| Background | The four human glycoprotein hormones chorionic gonadotropin (CG) , luteinizing hormone (LH) , follicle stimulating hormone (FSH) , and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. The four human glycoprotein hormones chorionic gonadotropin (CG) , luteinizing hormone (LH) , follicle stimulating hormone (FSH) , and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
