| Function | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. |
| Protein Name | Trna-Splicing Endonuclease Subunit Sen15Sen15 HomologHssen15Trna-Intron Endonuclease Sen15 |
| Database Links | Reactome: R-HSA-6784531 |
| Cellular Localisation | NucleusNucleolusMay Be Transiently Localized In The Nucleolus |
| Alternative Antibody Names | Anti-Trna-Splicing Endonuclease Subunit Sen15 antibodyAnti-Sen15 Homolog antibodyAnti-Hssen15 antibodyAnti-Trna-Intron Endonuclease Sen15 antibodyAnti-TSEN15 antibodyAnti-C1orf19 antibodyAnti-SEN15 antibody |
Information sourced from Uniprot.org
