| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRRAP (3660-3859) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRRAP |
| Gene ID: |
8295 |
| Uniprot ID: |
TRRAP_HUMAN |
| Immunogen Region: |
3660-3859 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 3660-3859 of TRRAP (NP_001231509.1). |
| Immunogen Sequence: |
PNATDYWTFRKMFTIQLALI GFAEFVLHLNRLNPEMLQIA QDTGKLNVAYFRFDINDATG DLDANRPVPFRLTPNISEFL TTIGVSGPLTASMIAVARCF AQPNFKVDGILKTVLRDEII AWHKKTQEDTSSPLSAAGQP ENMDSQQLVSLVQKAVTAIM TRLHNLAQFEGGESKVNTLV AAANSLDNLCRMDPAWHPWL |
| Function | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system. |
| Protein Name | Transformation/Transcription Domain-Associated Protein350/400 Kda Pcaf-Associated FactorPaf350/400Staf40Tra1 Homolog |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transformation/Transcription Domain-Associated Protein antibodyAnti-350/400 Kda Pcaf-Associated Factor antibodyAnti-Paf350/400 antibodyAnti-Staf40 antibodyAnti-Tra1 Homolog antibodyAnti-TRRAP antibodyAnti-PAF400 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
