| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transient receptor potential cation channel subfamily V member 5 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRPV5 |
| Gene ID: | 56302 |
| Uniprot ID: | TRPV5_HUMAN |
| Specificity: | TRPV5 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5 Trpv5 Calcium Transport Protein 2 Cat2 Epithelial Calcium Channel 1 Ecac Ecac1 Osm-9-Like Trp Channel 3 Otrpc3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Colocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular Cells The Expression Of The Glycosylated Form In The Cell Membrane Is Increased In The Presence Of Wnk3 |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibody Anti-Trpv5 antibody Anti-Calcium Transport Protein 2 antibody Anti-Cat2 antibody Anti-Epithelial Calcium Channel 1 antibody Anti-Ecac antibody Anti-Ecac1 antibody Anti-Osm-9-Like Trp Channel 3 antibody Anti-Otrpc3 antibody Anti-TRPV5 antibody Anti-ECAC1 antibody |
Information sourced from Uniprot.org