Anti-TRPM8 antibody (STJ193104)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TRPM8
Gene ID:	79054
Uniprot ID:	TRPM8_HUMAN
Specificity:	TRPM8 Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Function	Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Protein Name	Transient Receptor Potential Cation Channel Subfamily M Member 8 Long Transient Receptor Potential Channel 6 Ltrpc-6 Ltrpc6 Transient Receptor Potential P8 Trp-P8
Database Links	Reactome: R-HSA-3295583
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Membrane Raft Endoplasmic Reticulum Membrane Localizes To Membrane Rafts But Is Also Located In The Cell Membrane Outside Of These Regions Where Channel Response To Cold Is Enhanced Compared To Membrane Rafts Located In The Endoplasmic Reticulum In Prostate Cancer Cells
Alternative Antibody Names	Anti-Transient Receptor Potential Cation Channel Subfamily M Member 8 antibody Anti-Long Transient Receptor Potential Channel 6 antibody Anti-Ltrpc-6 antibody Anti-Ltrpc6 antibody Anti-Transient Receptor Potential P8 antibody Anti-Trp-P8 antibody Anti-TRPM8 antibody Anti-LTRPC6 antibody Anti-TRPP8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance