Anti-TRPM8 antibody {FITC} (STJ503413)

SKU:
STJ503413-100

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Host: Rabbit
Applications: ELISA/WB
Reactivity: Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TRPM8 is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.6 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Trpm8
Gene ID: 171384
Uniprot ID: TRPM8_RAT
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on TRPM8 protein.
Tissue Specificity Expressed in dorsal root and trigeminal ganglia. Specifically expressed in a subset of sensory neurons, including cold-sensitive neurons in trigeminal neurons.
Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 8
Cold Menthol Receptor 1
Database Links Reactome: R-RNO-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Membrane Raft
Localizes To Membrane Rafts But Is Also Located In The Cell Membrane Outside Of These Regions Where Channel Response To Cold Is Enhanced Compared To Membrane Rafts
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 8 antibody
Anti-Cold Menthol Receptor 1 antibody
Anti-Trpm8 antibody
Anti-Cmr1 antibody

Information sourced from Uniprot.org

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