Anti-TRPM7 antibody (Extracellular region) (STJA0005617)

SKU:
STJA0005617-100

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TRPM7 (Extracellular region) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:500
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPM7
Gene ID: 54822
Uniprot ID: TRPM7_HUMAN
Immunogen Region: Extracellular region
Specificity: This antibody detects a 220 kDa* protein on SDS-PAGE immunoblots of human MCF7, MDA-MB-231, mouse brain, and rat PC12 cells.
Immunogen: TRPM7 synthetic peptide (coupled to carrier) corresponding to amino acids in the extracellular region of human TRPM7. This site is well conserved in rat and mouse TRPM7, but has low homology to other TRPM family members.
Function Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 7
Channel-Kinase 1
Long Transient Receptor Potential Channel 7
Ltrpc-7
Ltrpc7
Database Links Reactome: R-HSA-3295583
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 7 antibody
Anti-Channel-Kinase 1 antibody
Anti-Long Transient Receptor Potential Channel 7 antibody
Anti-Ltrpc-7 antibody
Anti-Ltrpc7 antibody
Anti-TRPM7 antibody
Anti-CHAK1 antibody
Anti-LTRPC7 antibody

Information sourced from Uniprot.org

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