| Tissue Specificity | Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells. |
| Post Translational Modifications | Autophosphorylated.autophosphorylation controlls the protein kinase activity of TRPM6 towards their substrates. Autophosphorylation of Thr-1851 in the kinase domain is essential for the inhibitory effect of RACK1. The C-terminus of TRPM6 is proteolytically cleaved in vivo, in a cell type-specific fashion, releasing the kinase module from the transmembrane domain. The cleaved kinase fragments are translocated to the nucleus to phosphorylate histones and regulate gene expression. |
| Function | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. Crucial for Mg(2+) homeostasis. Has an important role in epithelial Mg(2+) transport and in the active Mg(2+) absorption in the gut and kidney. However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate. TRPM6 kinase, cleaved form: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and development. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 6Channel Kinase 2Melastatin-Related Trp Cation Channel 6 Cleaved Into - Trpm6 Kinase - Cleaved Form |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneTrpm6 Requires The Presence Of Trpm7 To Be Targeted To The Cell Membrane (In Hek 293 Cells)Trpm6 KinaseCleaved Form: Nucleus |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 6 antibodyAnti-Channel Kinase 2 antibodyAnti-Melastatin-Related Trp Cation Channel 6 Cleaved Into - Trpm6 Kinase - Cleaved Form antibodyAnti-TRPM6 antibodyAnti-CHAK2 antibody |
Information sourced from Uniprot.org
