Anti-TRPM3 antibody (666-716 aa) (STJ195274)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TRPM3 at the amino acid range 666-716
General Information
| Short Description | Rabbit polyclonal anti-Transient receptor potential cation channel subfamily M member 3 (666-716 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRPM3 |
| Gene ID | 80036 |
| Uniprot ID | TRPM3_HUMAN |
| Immunogen | Synthesized peptide derived from the human TRPM3 at the amino acid range 666-716 |
| Immunogen Region | 666-716 aa |
| Specificity | This antibody detects endogenous levels of TRPM3 at Human |
Additional Info
| Function | Constitutively active, non-selective divalent cation-conducting channel that is permeable to Ca(2+), Mn(2+), and Mg(2+), with a high permeability for Ca(2+). However, can be enhanced by increasing temperature and by ligands, including the endogenous neurosteroid pregnenolone sulfate and sphingosine-1 and suppressed by intracellular Mg(2+). Implicated in a variety of cellular processes, including insulin/peptide secretion, vascular constriction and dilation, noxious heat sensing, inflammatory and spontaneous pain sensitivity. In neurons of the dorsal root ganglia, functions as thermosensitive channel for the detection of noxious heat and spontaneous pain. Suggested to function as an ionotropic steroid receptor in beta-cell, indeed pregnenolone sulfate leads to Ca(2+) influx and enhanced insulin secretion. Mediates Zn(2+) uptake into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. Forms heteromultimeric ion channels with TRPM1 which are permeable for Ca(2+) and Zn(2+) ions. Exists as multiple splice variants which differ significantly in their biophysical properties. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 3Long Transient Receptor Potential Channel 3Ltrpc-3Ltrpc3Melastatin-2Mlsn2 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 3 antibodyAnti-Long Transient Receptor Potential Channel 3 antibodyAnti-Ltrpc-3 antibodyAnti-Ltrpc3 antibodyAnti-Melastatin-2 antibodyAnti-Mlsn2 antibodyAnti-TRPM3 antibodyAnti-KIAA1616 antibodyAnti-LTRPC3 antibody |
Information sourced from Uniprot.org