Anti-TRPM1 antibody (STJA0008543)

SKU:
STJA0008543

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transient receptor potential cation channel subfamily M member 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPM1
Gene ID: 4308
Uniprot ID: TRPM1_HUMAN
Specificity: This antibody detects endogenous levels of TRPM1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human TRPM1
Function Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells. In the dark, tonic release of glutamate activates the G-protein coupled receptor for glutamate, GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization. May play a role in metastasis suppression.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 1
Long Transient Receptor Potential Channel 1
Ltrpc1
Melastatin-1
Database Links Reactome: R-HSA-3295583
Reactome: R-HSA-9824594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Projection
Axon
In On-Bipolar Cells Is Intracellular And Located Predominantly In The Er
And Not At The Plasma Membrane Or Golgi Apparatus
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 1 antibody
Anti-Long Transient Receptor Potential Channel 1 antibody
Anti-Ltrpc1 antibody
Anti-Melastatin-1 antibody
Anti-TRPM1 antibody
Anti-LTRPC1 antibody
Anti-MLSN antibody
Anti-MLSN1 antibody

Information sourced from Uniprot.org

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