| Host: | Goat |
| Applications: | Pep-ELISA/WB/FC |
| Reactivity: | Human/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TRPC6 (C-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 100kDa band observed in lysates of cell line A549 (calculated MW of 106kDa according to NP_004612.2). Preliminary experiments also showed 100kDa in Human Lung lysates and in lysa |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TRPC6 |
| Gene ID: | 7225 |
| Uniprot ID: | TRPC6_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_004612.2 |
| Immunogen Sequence: | EKLSMEPNQEETN |
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6Trpc6Transient Receptor Protein 6Trp-6 |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibodyAnti-Trpc6 antibodyAnti-Transient Receptor Protein 6 antibodyAnti-Trp-6 antibodyAnti-TRPC6 antibodyAnti-TRP6 antibody |
Information sourced from Uniprot.org