| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIP10 (246-545) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIP10 |
| Gene ID: |
9322 |
| Uniprot ID: |
CIP4_HUMAN |
| Immunogen Region: |
246-545 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1). |
| Immunogen Sequence: |
AKCLEGMKVAANAVDPKNDS HVLIELHKSGFARPGDVEFE DFSQPMNRAPSDSSLGTPSD GRPELRGPGRSRTKRWPFGK KNKTVVTEDFSHLPPEQQRK RLQQQLEERSRELQKEVDQR EALKKMKDVYEKTPQMGDPA SLEPQIAETLSNIERLKLEV QKYEAWLAEAESRVLSNRGD SLSRHARPPDPPASAPPDSS SNSASQDTKESSEEPPSEES QDTPIYTEFDEDFEEEPTS |
| Tissue Specificity | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
| Post Translational Modifications | Tyrosine phosphorylated. Also phosphorylated by PKA. |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Cdc42-Interacting Protein 4Protein FelicSalt Tolerant ProteinHstpThyroid Receptor-Interacting Protein 10Tr-Interacting Protein 10Trip-10 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeGolgi ApparatusCell MembraneCell ProjectionPhagocytic CupTranslocates To The Plasma Membrane In Response To Insulin StimulationAnd This May Require Active RhoqLocalizes To Cortical Regions Coincident With F-ActinTo Lysosomes And To Sites Of Phagocytosis In MacrophagesAlso Localizes To The GolgiAnd This Requires Akap9Isoform 5: CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Cdc42-Interacting Protein 4 antibodyAnti-Protein Felic antibodyAnti-Salt Tolerant Protein antibodyAnti-Hstp antibodyAnti-Thyroid Receptor-Interacting Protein 10 antibodyAnti-Tr-Interacting Protein 10 antibodyAnti-Trip-10 antibodyAnti-TRIP10 antibodyAnti-CIP4 antibodyAnti-STOT antibodyAnti-STP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
