| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim8Glioblastoma-Expressed Ring Finger ProteinRing Finger Protein 27Ring-Type E3 Ubiquitin Transferase Trim8Tripartite Motif-Containing Protein 8 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleusNuclear BodyNucleo-Cytoplasmic Translocation Is Involved In Regulation Of Nf-Kappa-B |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim8 antibodyAnti-Glioblastoma-Expressed Ring Finger Protein antibodyAnti-Ring Finger Protein 27 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim8 antibodyAnti-Tripartite Motif-Containing Protein 8 antibodyAnti-TRIM8 antibodyAnti-GERP antibodyAnti-RNF27 antibody |
Information sourced from Uniprot.org
