• Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-TRIM63 antibody (STJ190795)

SKU:
STJ190795

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase TRIM63 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRIM63
Gene ID: 84676
Uniprot ID: TRI63_HUMAN
Specificity: TRI63 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Protein Name E3 Ubiquitin-Protein Ligase Trim63
Iris Ring Finger Protein
Muscle-Specific Ring Finger Protein 1
Murf-1
Murf1
Ring Finger Protein 28
Ring-Type E3 Ubiquitin Transferase Trim63
Striated Muscle Ring Zinc Finger Protein
Tripartite Motif-Containing Protein 63
Database Links Reactome: R-HSA-9615017
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Myofibril
Sarcomere
M Line
Z Line
Colocalizes With Tnni3 In Myocytes
Localizes To The M- And Z-Lines In Skeletal Muscle
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Trim63 antibody
Anti-Iris Ring Finger Protein antibody
Anti-Muscle-Specific Ring Finger Protein 1 antibody
Anti-Murf-1 antibody
Anti-Murf1 antibody
Anti-Ring Finger Protein 28 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Trim63 antibody
Anti-Striated Muscle Ring Zinc Finger Protein antibody
Anti-Tripartite Motif-Containing Protein 63 antibody
Anti-TRIM63 antibody
Anti-IRF antibody
Anti-MURF1 antibody
Anti-RNF28 antibody
Anti-SMRZ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance