Anti-TRIM62 antibody (120-280) (STJ118300)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRIM62 (120-280) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM62 |
| Gene ID | 55223 |
| Uniprot ID | TRI62_HUMAN |
| Immunogen Region | 120-280 |
| Immunogen Sequence | HEQHQVTGIDDAFDELQREL KDQLQALQDSEREHTEALQL LKRQLAETKSSTKSLRTTIG EAFERLHRLLRERQKAMLEE LEADTARTLTDIEQKVQRYS QQLRKVQEGAQILQERLAET DRHTFLAGVASLSERLKGKI HETNLTYEDFPTSKYTGPLQ Y |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human TRIM62 (NP_060677.2). |
Additional Info
| Post Translational Modifications | Polyubiquitinated, autoubiquitinated in the presence of UBE2D2. |
| Function | E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors.leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim62Tripartite Motif-Containing Protein 62 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim62 antibodyAnti-Tripartite Motif-Containing Protein 62 antibodyAnti-TRIM62 antibody |
Information sourced from Uniprot.org