Anti-TRIM45 antibody (STJA0009772)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TRIM45
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase TRIM45 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM45 |
| Gene ID | 80263 |
| Uniprot ID | TRI45_HUMAN |
| Immunogen | Synthesized peptide derived from human TRIM45 |
| Specificity | This antibody detects endogenous levels of TRIM45 at Human, Mouse |
Additional Info
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim45Ring Finger Protein 99 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim45 antibodyAnti-Ring Finger Protein 99 antibodyAnti-TRIM45 antibodyAnti-RNF99 antibody |
Information sourced from Uniprot.org