| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim41Ring Finger-Interacting Protein With C KinaseRinckTripartite Motif-Containing Protein 41 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim41 antibodyAnti-Ring Finger-Interacting Protein With C Kinase antibodyAnti-Rinck antibodyAnti-Tripartite Motif-Containing Protein 41 antibodyAnti-TRIM41 antibodyAnti-RINCK antibody |
Information sourced from Uniprot.org
