| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim33Ectodermin HomologRet-Fused Gene 7 ProteinProtein Rfg7Ring-Type E3 Ubiquitin Transferase Trim33Transcription Intermediary Factor 1-GammaTif1-GammaTripartite Motif-Containing Protein 33 |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-9754189 |
| Cellular Localisation | NucleusIn Discrete Nuclear Dots Resembling Nuclear BodiesLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim33 antibodyAnti-Ectodermin Homolog antibodyAnti-Ret-Fused Gene 7 Protein antibodyAnti-Protein Rfg7 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim33 antibodyAnti-Transcription Intermediary Factor 1-Gamma antibodyAnti-Tif1-Gamma antibodyAnti-Tripartite Motif-Containing Protein 33 antibodyAnti-TRIM33 antibodyAnti-KIAA1113 antibodyAnti-RFG7 antibodyAnti-TIF1G antibody |
Information sourced from Uniprot.org
