| Tissue Specificity | Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors. |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim33Ectodermin HomologRet-Fused Gene 7 ProteinProtein Rfg7Ring-Type E3 Ubiquitin Transferase Trim33Transcription Intermediary Factor 1-GammaTif1-GammaTripartite Motif-Containing Protein 33 |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-9754189 |
| Cellular Localisation | NucleusIn Discrete Nuclear Dots Resembling Nuclear BodiesLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim33 antibodyAnti-Ectodermin Homolog antibodyAnti-Ret-Fused Gene 7 Protein antibodyAnti-Protein Rfg7 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim33 antibodyAnti-Transcription Intermediary Factor 1-Gamma antibodyAnti-Tif1-Gamma antibodyAnti-Tripartite Motif-Containing Protein 33 antibodyAnti-TRIM33 antibodyAnti-KIAA1113 antibodyAnti-RFG7 antibodyAnti-TIF1G antibody |
Information sourced from Uniprot.org
