| Tissue Specificity | Expressed in breast tumors (at protein level). Ubiquitous. |
| Post Translational Modifications | Auto-ISGylated. (Microbial infection) Autoubiquitinated.promoted by Epstein-Barr virus protein BPLF1. |
| Function | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3. Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks. Plays an essential role in the antiviral activity of ZAP/ZC3HAV1.an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA. Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability. |
| Protein Name | E3 Ubiquitin/Isg15 Ligase Trim25Estrogen-Responsive Finger ProteinRing Finger Protein 147Ring-Type E3 Ubiquitin TransferaseRing-Type E3 Ubiquitin Transferase Trim25Tripartite Motif-Containing Protein 25Ubiquitin/Isg15-Conjugating Enzyme Trim25Zinc Finger Protein 147 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168928Reactome: R-HSA-5656169Reactome: R-HSA-5689896Reactome: R-HSA-877300Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-933542Reactome: R-HSA-933543Reactome: R-HSA-936440Reactome: R-HSA-9692916Reactome: R-HSA-9705671Reactome: R-HSA-9833109Reactome: R-HSA-9833110Reactome: R-HSA-9833482Reactome: R-HSA-9909505 |
| Cellular Localisation | CytoplasmStress GranuleNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin/Isg15 Ligase Trim25 antibodyAnti-Estrogen-Responsive Finger Protein antibodyAnti-Ring Finger Protein 147 antibodyAnti-Ring-Type E3 Ubiquitin Transferase antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim25 antibodyAnti-Tripartite Motif-Containing Protein 25 antibodyAnti-Ubiquitin/Isg15-Conjugating Enzyme Trim25 antibodyAnti-Zinc Finger Protein 147 antibodyAnti-TRIM25 antibodyAnti-EFP antibodyAnti-RNF147 antibodyAnti-ZNF147 antibody |
Information sourced from Uniprot.org
