| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM13 (40-310) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM13 |
| Gene ID: |
10206 |
| Uniprot ID: |
TRI13_HUMAN |
| Immunogen Region: |
40-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human TRIM13 (NP_001007279.1). |
| Immunogen Sequence: |
ILEGSVRNSLWRPAPFKCPT CRKETSATGINSLQVNYSLK GIVEKYNKIKISPKMPVCKG HLGQPLNIFCLTDMQLICGI CATRGEHTKHVFCSIEDAYA QERDAFESLFQSFETWRRGD ALSRLDTLETSKRKSLQLLT KDSDKVKEFFEKLQHTLDQK KNEILSDFETMKLAVMQAYD PEINKLNTILQEQRMAFNIA EAFKDVSEPIVFLQQMQEFR EKIKVIKETPLPPSNLPAS |
| Post Translational Modifications | Auto-ubiquitinated.requires the RING-type zinc finger. Auto-polyubiquitination leads to proteasomal degradation. |
| Function | Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim13B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5Leukemia-Associated Protein 5Putative Tumor Suppressor Rfp2Ring Finger Protein 77Ring-Type E3 Ubiquitin Transferase Trim13Ret Finger Protein 2Tripartite Motif-Containing Protein 13 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinConcentrates And Colocalizes With P62/Sqstm1 And Zfyve1 At The Perinuclear Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim13 antibodyAnti-B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5 antibodyAnti-Leukemia-Associated Protein 5 antibodyAnti-Putative Tumor Suppressor Rfp2 antibodyAnti-Ring Finger Protein 77 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim13 antibodyAnti-Ret Finger Protein 2 antibodyAnti-Tripartite Motif-Containing Protein 13 antibodyAnti-TRIM13 antibodyAnti-LEU5 antibodyAnti-RFP2 antibodyAnti-RNF77 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
