Anti-Transglutaminase 3 antibody (598-610) (STJ72645)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Transglutaminase 3 (598-610) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 80kDa band observed in Human Tonsil lysates (calculated MW of 76.6kDa according to NP_003236.3). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TGM3 |
| Gene ID | 7053 |
| Uniprot ID | TGM3_HUMAN |
| Accession Number | NP_003236.3 |
| Immunogen Region | 598-610 |
| Immunogen Sequence | TLEVLNEARVRKP |
Additional Info
| Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. |
| Protein Name | Protein-Glutamine Gamma-Glutamyltransferase ETransglutaminase ETg(ETgeTgase ETransglutaminase-3Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein-Glutamine Gamma-Glutamyltransferase E antibodyAnti-Transglutaminase E antibodyAnti-Tg(E antibodyAnti-Tge antibodyAnti-Tgase E antibodyAnti-Transglutaminase-3 antibodyAnti-Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain antibodyAnti-TGM3 antibody |
Information sourced from Uniprot.org