Anti-Transcriptional Enhancer Factor TEF 1 antibody [R05-1H3] (STJA0034922)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human TEAD-1
General Information
| Short Description | Rabbit monoclonal anti-Transcriptional Enhancer Factor TEF 1 for use in WB in Human, Rat and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-1H3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TEAD1 |
| Gene ID | 7003 |
| Uniprot ID | TEAD1_HUMAN |
| Immunogen | A synthetic peptide of human TEAD-1 |
Additional Info
| Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Post Translational Modifications | Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway. Delactylated by SIRT1. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-1Ntef-1Protein Gt-IicTea Domain Family Member 1Tead-1Transcription Factor 13Tcf-13 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-1 antibodyAnti-Ntef-1 antibodyAnti-Protein Gt-Iic antibodyAnti-Tea Domain Family Member 1 antibodyAnti-Tead-1 antibodyAnti-Transcription Factor 13 antibodyAnti-Tcf-13 antibodyAnti-TEAD1 antibodyAnti-TCF13 antibodyAnti-TEF1 antibody |
Information sourced from Uniprot.org