| Post Translational Modifications | Sumoylated on Lys-10.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions. TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation. At the 8-cell stage, during morula development, controls expression of cell-polarity genes. Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2. Binds to both closed and open chromatin with other transcription factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
| Protein Name | Transcription Factor Ap-2 GammaAp2-GammaActivating Enhancer-Binding Protein 2 GammaTranscription Factor Erf-1 |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-8866904Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-8866911Reactome: R-HSA-9827857Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2 Gamma antibodyAnti-Ap2-Gamma antibodyAnti-Activating Enhancer-Binding Protein 2 Gamma antibodyAnti-Transcription Factor Erf-1 antibodyAnti-TFAP2C antibody |
Information sourced from Uniprot.org
