| Function | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT). |
| Protein Name | Translocating Chain-Associated Membrane Protein 2 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Translocating Chain-Associated Membrane Protein 2 antibodyAnti-TRAM2 antibodyAnti-KIAA0057 antibody |
Information sourced from Uniprot.org
