Anti-TRAK1 antibody (STJ191519)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Trafficking kinesin-binding protein 1 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRAK1 |
| Gene ID | 22906 |
| Uniprot ID | TRAK1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TRAK1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | O-glycosylated. Glycosylated by OGT.glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT. |
| Function | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. |
| Protein Name | Trafficking Kinesin-Binding Protein 1106 Kda O-Glcnac Transferase-Interacting ProteinProtein Milton |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-9013419Reactome: R-HSA-9013425 |
| Cellular Localisation | CytoplasmNucleusMitochondrionEarly EndosomeEndosomeMitochondrion MembraneCell CortexPredominantly Associated With Early EndosomeThe Localization To Early Endosomes Depends On Its Interaction With Hgs/HrsColocalizes With Mgarp At The Mitochondria |
| Alternative Antibody Names | Anti-Trafficking Kinesin-Binding Protein 1 antibodyAnti-106 Kda O-Glcnac Transferase-Interacting Protein antibodyAnti-Protein Milton antibodyAnti-TRAK1 antibodyAnti-KIAA1042 antibodyAnti-OIP106 antibody |
Information sourced from Uniprot.org