| Tissue Specificity | Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. |
| Post Translational Modifications | Polyubiquitinated, leading to its proteasomal degradation. Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
| Function | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway. |
| Protein Name | Tnf Receptor-Associated Factor 4Cysteine-Rich Domain Associated With Ring And Traf Domains Protein 1Metastatic Lymph Node Gene 62 ProteinMln 62Ring Finger Protein 83 |
| Cellular Localisation | CytoplasmNucleusPerinuclear RegionCell JunctionTight JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoskeleton |
| Alternative Antibody Names | Anti-Tnf Receptor-Associated Factor 4 antibodyAnti-Cysteine-Rich Domain Associated With Ring And Traf Domains Protein 1 antibodyAnti-Metastatic Lymph Node Gene 62 Protein antibodyAnti-Mln 62 antibodyAnti-Ring Finger Protein 83 antibodyAnti-TRAF4 antibodyAnti-CART1 antibodyAnti-MLN62 antibodyAnti-RNF83 antibody |
Information sourced from Uniprot.org
