| Function | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. |
| Protein Name | Ubiquitin Thioesterase Zranb1Traf-Binding Domain-Containing ProteinHtrabidZinc Finger Ran-Binding Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusEnriched In Punctate Localization In The Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin Thioesterase Zranb1 antibodyAnti-Traf-Binding Domain-Containing Protein antibodyAnti-Htrabid antibodyAnti-Zinc Finger Ran-Binding Domain-Containing Protein 1 antibodyAnti-ZRANB1 antibodyAnti-TRABID antibody |
Information sourced from Uniprot.org
