• Western blot analysis of lysates from COLO205, HUVEC, and HepG2 cells, using TP53INP1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HT-29 cells using TP53INP1 antibody.
  • Western blot analysis of various cells using TP53INP1 Polyclonal Antibody diluted at 1：1000. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-TP53INP1 antibody (171-220 aa) (STJ96070)

SKU:
STJ96070

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Tumor protein p53-inducible nuclear protein 1 (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TP53INP1
Gene ID: 94241
Uniprot ID: T53I1_HUMAN
Immunogen Region: 171-220 aa
Specificity: TP53INP1 Polyclonal Antibody detects endogenous levels of TP53INP1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TP53INP1 at the amino acid range 171-220
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Protein Name Tumor Protein P53-Inducible Nuclear Protein 1
Stress-Induced Protein
P53-Dependent Damage-Inducible Nuclear Protein 1
P53dinp1
Database Links Reactome: R-HSA-6803204
Reactome: R-HSA-6804756
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Pml Body
Cytoplasmic Vesicle
Autophagosome
Shuttles Between The Nucleus And The Cytoplasm
Depending On Cellular Stress Conditions
And Re-Localizes To Autophagosomes On Autophagy Activation
Alternative Antibody Names Anti-Tumor Protein P53-Inducible Nuclear Protein 1 antibody
Anti-Stress-Induced Protein antibody
Anti-P53-Dependent Damage-Inducible Nuclear Protein 1 antibody
Anti-P53dinp1 antibody
Anti-TP53INP1 antibody
Anti-P53DINP1 antibody
Anti-SIP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance