| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Torsin-1A-interacting protein 1 (431-480 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TOR1AIP1 |
| Gene ID: | 26092 |
| Uniprot ID: | TOIP1_HUMAN |
| Immunogen Region: | 431-480 aa |
| Specificity: | LAP1B Polyclonal Antibody detects endogenous levels of LAP1B protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TOR1AIP1 at the amino acid range 431-480 |
| Post Translational Modifications | Phosphorylated. Dephosphorylated at Ser-309 and Ser-315 by serine/threonine-protein phosphatase PP1. |
| Function | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. |
| Protein Name | Torsin-1a-Interacting Protein 1Lamin-Associated Protein 1bLap1b |
| Database Links | Reactome: R-HSA-9013405Reactome: R-HSA-9035034 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Membrane ProteinIsoform 4: Nucleus EnvelopeNucleusFound Mainly In The Nuclear Envelope And Also Inside The Nucleus |
| Alternative Antibody Names | Anti-Torsin-1a-Interacting Protein 1 antibodyAnti-Lamin-Associated Protein 1b antibodyAnti-Lap1b antibodyAnti-TOR1AIP1 antibodyAnti-LAP1 antibody |
Information sourced from Uniprot.org