Anti-TOLLIP antibody (Internal) (STJ96060)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human Tollip.
General Information
| Short Description | Rabbit polyclonal anti-Toll-interacting protein (Internal) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TOLLIP |
| Gene ID | 54472 |
| Uniprot ID | TOLIP_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human Tollip. |
| Immunogen Region | Internal |
| Specificity | Tollip Polyclonal Antibody detects endogenous levels of Tollip protein. |
Additional Info
| Function | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P). |
| Protein Name | Toll-Interacting Protein |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmEndosomeEarly EndosomeLocalized To Endo/Exosomal Vesicles |
| Alternative Antibody Names | Anti-Toll-Interacting Protein antibodyAnti-TOLLIP antibody |
Information sourced from Uniprot.org