Anti-TNS4 antibody (STJA0007769)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TNS4
General Information
| Short Description | Rabbit polyclonal anti-Tensin-4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNS4 |
| Gene ID | 84951 |
| Uniprot ID | TENS4_HUMAN |
| Immunogen | Synthesized peptide derived from human TNS4 |
| Specificity | This antibody detects endogenous levels of TNS4 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. |
| Protein Name | Tensin-4C-Terminal Tensin-Like Protein |
| Database Links | Reactome: R-HSA-8875513 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tensin-4 antibodyAnti-C-Terminal Tensin-Like Protein antibodyAnti-TNS4 antibodyAnti-CTEN antibodyAnti-PP14434 antibody |
Information sourced from Uniprot.org