| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Poly polymerase tankyrase-2 (950-1030 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNKS2 |
| Gene ID: |
80351 |
| Uniprot ID: |
TNKS2_HUMAN |
| Immunogen Region: |
950-1030 aa |
| Specificity: |
TNKS2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 950-1030 |
| Post Translational Modifications | Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-2Adp-Ribosyltransferase Diphtheria Toxin-Like 6Artd6Poly Adp-Ribose Polymerase 5bProtein Poly-Adp-Ribosyltransferase Tankyrase-2Tnks-2Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2Tankyrase IiTankyrase-2Tank2Tankyrase-Like ProteinTankyrase-Related Protein |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinNucleusChromosomeTelomereAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesAlso Found Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks2 Is Found In The NucleusAssociated With Trf1 |
| Alternative Antibody Names | Anti-Poly Adp-Ribose Polymerase Tankyrase-2 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 6 antibodyAnti-Artd6 antibodyAnti-Poly Adp-Ribose Polymerase 5b antibodyAnti-Protein Poly-Adp-Ribosyltransferase Tankyrase-2 antibodyAnti-Tnks-2 antibodyAnti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 antibodyAnti-Tankyrase Ii antibodyAnti-Tankyrase-2 antibodyAnti-Tank2 antibodyAnti-Tankyrase-Like Protein antibodyAnti-Tankyrase-Related Protein antibodyAnti-TNKS2 antibodyAnti-PARP5B antibodyAnti-TANK2 antibodyAnti-TNKL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
