Anti-TNKS2 antibody (950-1030 aa) (STJ192500)

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STJ192500
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Poly polymerase tankyrase-2 (950-1030 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNKS2
Gene ID: 80351
Uniprot ID: TNKS2_HUMAN
Immunogen Region: 950-1030 aa
Specificity: TNKS2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 950-1030
Post Translational Modifications Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated.this leads to degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
Protein Name Poly Adp-Ribose Polymerase Tankyrase-2
Adp-Ribosyltransferase Diphtheria Toxin-Like 6
Artd6
Poly Adp-Ribose Polymerase 5b
Protein Poly-Adp-Ribosyltransferase Tankyrase-2
Tnks-2
Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2
Tankyrase Ii
Tankyrase-2
Tank2
Tankyrase-Like Protein
Tankyrase-Related Protein
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4641257
Reactome: R-HSA-5545619
Reactome: R-HSA-5689880
Reactome: R-HSA-8948751
Cellular Localisation Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Nucleus
Chromosome
Telomere
Associated With The Golgi And With Juxtanuclear Slc2a4/Glut4-Vesicles
Also Found Around The Pericentriolar Matrix Of Mitotic Centromeres
During Interphase
A Small Fraction Of Tnks2 Is Found In The Nucleus
Associated With Trf1
Alternative Antibody Names Anti-Poly Adp-Ribose Polymerase Tankyrase-2 antibody
Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 6 antibody
Anti-Artd6 antibody
Anti-Poly Adp-Ribose Polymerase 5b antibody
Anti-Protein Poly-Adp-Ribosyltransferase Tankyrase-2 antibody
Anti-Tnks-2 antibody
Anti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase 2 antibody
Anti-Tankyrase Ii antibody
Anti-Tankyrase-2 antibody
Anti-Tank2 antibody
Anti-Tankyrase-Like Protein antibody
Anti-Tankyrase-Related Protein antibody
Anti-TNKS2 antibody
Anti-PARP5B antibody
Anti-TANK2 antibody
Anti-TNKL antibody

Information sourced from Uniprot.org

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