Anti-TNIP2 antibody (61-110 aa) (STJ98808)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 61-110
General Information
| Short Description | Rabbit polyclonal anti-TNFAIP3-interacting protein 2 (61-110 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNIP2 |
| Gene ID | 79155 |
| Uniprot ID | TNIP2_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 61-110 |
| Immunogen Region | 61-110 aa |
| Specificity | The antibody detects endogenous Abin-2 |
Additional Info
| Post Translational Modifications | In vitro phosphorylated by CHUK. Ubiquitinated.undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination. Deubiquitinated by USP35.leading to stabilization and inhibition of TNFalpha-induced NF-kappa-B activation. |
| Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response.this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells.promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. |
| Protein Name | Tnfaip3-Interacting Protein 2A20-Binding Inhibitor Of Nf-Kappa-B Activation 2Abin-2Fetal Liver Lkb1-Interacting Protein |
| Database Links | Reactome: R-HSA-5684264Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Tnfaip3-Interacting Protein 2 antibodyAnti-A20-Binding Inhibitor Of Nf-Kappa-B Activation 2 antibodyAnti-Abin-2 antibodyAnti-Fetal Liver Lkb1-Interacting Protein antibodyAnti-TNIP2 antibodyAnti-ABIN2 antibodyAnti-FLIP1 antibody |
Information sourced from Uniprot.org