Anti-TNIK antibody (1250-1300) {FITC} (STJ503344)

SKU:
STJ503344-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TNIK (1250-1300) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TNIK
Gene ID: 23043
Uniprot ID: TNIK_HUMAN
Immunogen Region: 1250-1300
Immunogen: Sythetic peptide taken within amino acid region 1250-1300 on human TRAF2 and NCK-interacting protein kinase protein.
Tissue Specificity Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
Post Translational Modifications Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
Function Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Protein Name Traf2 And Nck-Interacting Protein Kinase
Database Links Reactome: R-HSA-2559580
Cellular Localisation Nucleus
Cytoplasm
Recycling Endosome
Cytoskeleton
Associated With Recycling Endosomes And The Cytoskeletal Fraction Upon Rap2a Overexpression
Alternative Antibody Names Anti-Traf2 And Nck-Interacting Protein Kinase antibody
Anti-TNIK antibody
Anti-KIAA0551 antibody

Information sourced from Uniprot.org

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