| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 12Apo3 LigandTnf-Related Weak Inducer Of ApoptosisTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 12Secreted Form: SecretedIsoform Twe-Pril: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 12 antibodyAnti-Apo3 Ligand antibodyAnti-Tnf-Related Weak Inducer Of Apoptosis antibodyAnti-Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form antibodyAnti-TNFSF12 antibodyAnti-APO3L antibodyAnti-DR3LG antibodyAnti-UNQ181 antibodyAnti-PRO207 antibody |
Information sourced from Uniprot.org
