| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF9 |
| Gene ID: | 3604 |
| Uniprot ID: | TNR9_HUMAN |
| Immunogen Region: | 164-255 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human 4-1BB/CD137 (NP_001552.2). |
| Immunogen Sequence: | SMCEQDCKQGQELTKKGCKD CCFGTFNDQKRGICRPWTNC SLDGKSVLVNGTKERDVVCG PSPADLSPGASSVTPPAPAR EPGHSPQIISFFLALTSTAL LFLLFFLTLRFSVVKRGRKK LLYIFKQPFMRPVQTTQEED GCSCRFPEEEEGGCEL |
| Tissue Specificity | Expressed on the surface of activated T-cells. |
| Function | Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 94-1bb Ligand ReceptorCdw137T-Cell Antigen 4-1bb HomologT-Cell Antigen IlaCd Antigen Cd137 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 9 antibodyAnti-4-1bb Ligand Receptor antibodyAnti-Cdw137 antibodyAnti-T-Cell Antigen 4-1bb Homolog antibodyAnti-T-Cell Antigen Ila antibodyAnti-Cd Antigen Cd137 antibodyAnti-TNFRSF9 antibodyAnti-CD137 antibodyAnti-ILA antibody |
Information sourced from Uniprot.org