| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tumor necrosis factor receptor superfamily member 1B (376-425 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF1B |
| Gene ID: | 7133 |
| Uniprot ID: | TNR1B_HUMAN |
| Immunogen Region: | 376-425 aa |
| Specificity: | TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TNF Receptor II at the amino acid range 376-425 |
| Function | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1b Tumor Necrosis Factor Receptor 2 Tnf-R2 Tumor Necrosis Factor Receptor Type Ii Tnf-Rii Tnfr-Ii P75 P80 Tnf-Alpha Receptor Cd Antigen Cd120b Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 Tbp-2 Tbpii |
| Database Links | Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Tumor Necrosis Factor-Binding Protein 2: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1b antibody Anti-Tumor Necrosis Factor Receptor 2 antibody Anti-Tnf-R2 antibody Anti-Tumor Necrosis Factor Receptor Type Ii antibody Anti-Tnf-Rii antibody Anti-Tnfr-Ii antibody Anti-P75 antibody Anti-P80 Tnf-Alpha Receptor antibody Anti-Cd Antigen Cd120b antibody Anti-Etanercept Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1b - Membrane Form - Tumor Necrosis Factor-Binding Protein 2 antibody Anti-Tbp-2 antibody Anti-Tbpii antibody Anti-TNFRSF1B antibody Anti-TNFBR antibody Anti-TNFR2 antibody |
Information sourced from Uniprot.org