| Host: | Rabbit |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF1A |
| Gene ID: | 7132 |
| Uniprot ID: | TNR1A_HUMAN |
| Immunogen Region: | 241-455 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 241-455 of human TNFR1/TNFR1/TNFRSF1A (NP_001056.1). |
| Immunogen Sequence: | SKLYSIVCGKSTPEKEGELE GTTTKPLAPNPSFSPTPGFT PTLGFSPVPSSTFTSSSTYT PGDCPNFAAPRREVAPPYQG ADPILATALASDPIPNPLQK WEDSAHKPQSLDTDDPATLY AVVENVPPLRWKEFVRRLGL SDHEIDRLELQNGRCLREAQ YSMLATWRRRTPRREATLEL LGRVLRDMDLLGCLEDIEEA LCGPAALPPAPSLLR |
| Post Translational Modifications | The soluble form is produced from the membrane form by proteolytic processing. (Microbial infection) Glycosylated at Arg-376 by enteropathogenic E.coli protein NleB1 and S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1a Tumor Necrosis Factor Receptor 1 Tnf-R1 Tumor Necrosis Factor Receptor Type I Tnf-Ri Tnfr-I P55 P60 Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 Tbpi |
| Database Links | Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-5357956 Reactome: R-HSA-5626978 Reactome: R-HSA-5669034 Reactome: R-HSA-6783783 Reactome: R-HSA-75893 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Membrane Secreted A Secreted Form Is Produced Through Proteolytic Processing Isoform 4: Secreted Lacks A Golgi-Retention Motif Is Not Membrane Bound And Therefore Is Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a antibody Anti-Tumor Necrosis Factor Receptor 1 antibody Anti-Tnf-R1 antibody Anti-Tumor Necrosis Factor Receptor Type I antibody Anti-Tnf-Ri antibody Anti-Tnfr-I antibody Anti-P55 antibody Anti-P60 antibody Anti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 antibody Anti-Tbpi antibody Anti-TNFRSF1A antibody Anti-TNFAR antibody Anti-TNFR1 antibody |
Information sourced from Uniprot.org