Anti-TNFRSF18 antibody (26-255) (STJ118073)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GITR/TNFRSF18 (26-255) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF18 |
| Gene ID | 8784 |
| Uniprot ID | TNR18_HUMAN |
| Immunogen Region | 26-255 |
| Immunogen Sequence | QRPTGGPGCGPGRLLLGTGT DARCCRVHTTRCCRDYPGEE CCSEWDCMCVQPEFHCGDPC CTTCRHHPCPPGQGVQSQGK FSFGFQCIDCASGTFSGGHE GHCKPWTDCCWRCRRRPKTP EAASSPRKSGASDRQRRRGG WETCGCEPGRPPGPPTAASP SPGAPQAAGALRSALGRALL PWQQKWVQEGGSDQRPGPCS SAAAAGPCRRERETQSWPPS SLAGPDGVGS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-255 of human GITR/TNFRSF18 (NP_683699.1). |
Additional Info
| Tissue Specificity | Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
| Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 18Activation-Inducible Tnfr Family ReceptorGlucocorticoid-Induced Tnfr-Related ProteinCd Antigen Cd357 |
| Database Links | Reactome: R-HSA-5669034Reactome: R-HSA-8877330 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 18 antibodyAnti-Activation-Inducible Tnfr Family Receptor antibodyAnti-Glucocorticoid-Induced Tnfr-Related Protein antibodyAnti-Cd Antigen Cd357 antibodyAnti-TNFRSF18 antibodyAnti-AITR antibodyAnti-GITR antibodyAnti-UNQ319 antibodyAnti-PRO364 antibody |
Information sourced from Uniprot.org