Anti-TNFRSF11B antibody [5G2] (STJ98290)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human OPG expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Tumor necrosis factor receptor superfamily member 11B for use in WB, IF, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 5G2 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000FC 1:200-1:400ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF11B |
| Gene ID | 4982 |
| Uniprot ID | TR11B_HUMAN |
| Immunogen | Purified recombinant fragment of human OPG expressed in E. Coli. |
| Specificity | OPG Monoclonal Antibody detects endogenous levels of OPG protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. |
| Function | Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11bOsteoclastogenesis Inhibitory FactorOsteoprotegerin |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 11b antibodyAnti-Osteoclastogenesis Inhibitory Factor antibodyAnti-Osteoprotegerin antibodyAnti-TNFRSF11B antibodyAnti-OCIF antibodyAnti-OPG antibody |
Information sourced from Uniprot.org