• Immunohistochemistry analysis of paraffin-embedded mammary cancer tissues (left) and lung cancer tissues (right) with DAB staining using OPG monoclonal antibody.
  • Western blot analysis using OPG monoclonal antibody against HEK293 (1) and OPG-hIgGFc transfected HEK293 (2) cell lysate.

Anti-TNFRSF11B antibody [5A11] (STJ98291)

SKU:
STJ98291

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Tumor necrosis factor receptor superfamily member 11B is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 5A11
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNFRSF11B
Gene ID: 4982
Uniprot ID: TR11B_HUMAN
Specificity: OPG Monoclonal Antibody detects endogenous levels of OPG protein.
Immunogen: Purified recombinant fragment of human OPG expressed in E. Coli.
Post Translational Modifications N-glycosylated. Contains sialic acid residues. The N-terminus is blocked.
Function Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 11b
Osteoclastogenesis Inhibitory Factor
Osteoprotegerin
Database Links Reactome: R-HSA-5669034
Cellular Localisation Secreted
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 11b antibody
Anti-Osteoclastogenesis Inhibitory Factor antibody
Anti-Osteoprotegerin antibody
Anti-TNFRSF11B antibody
Anti-OCIF antibody
Anti-OPG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance