| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tumor necrosis factor receptor superfamily member 10A (401-450 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF10A |
| Gene ID: | 8797 |
| Uniprot ID: | TR10A_HUMAN |
| Immunogen Region: | 401-450 aa |
| Specificity: | DR4 Polyclonal Antibody detects endogenous levels of DR4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TNFRSF10A at the amino acid range 401-450 |
| Post Translational Modifications | Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable). |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10aDeath Receptor 4Tnf-Related Apoptosis-Inducing Ligand Receptor 1Trail Receptor 1Trail-R1Cd Antigen Cd261 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCytoplasmCytosolPalmitoylation Is Required For Association With Membranes |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10a antibodyAnti-Death Receptor 4 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 1 antibodyAnti-Trail Receptor 1 antibodyAnti-Trail-R1 antibodyAnti-Cd Antigen Cd261 antibodyAnti-TNFRSF10A antibodyAnti-APO2 antibodyAnti-DR4 antibodyAnti-TRAILR1 antibody |
Information sourced from Uniprot.org
