Anti-TMEM9 antibody (STJA0004844)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human TMEM9
General Information
| Short Description | Rabbit polyclonal anti-Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.84 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEM9 |
| Gene ID | 252839 |
| Uniprot ID | TMEM9_HUMAN |
| Immunogen | Fusion protein of human TMEM9 |
Additional Info
| Tissue Specificity | Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression is detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin. |
| Post Translational Modifications | N-glycosylated. |
| Function | Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration. |
| Protein Name | Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9V-Atpase Assembly Regulator Tmem9Dermal Papilla-Derived Protein 4Transmembrane Protein 9Protein Tmem9 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinLate Endosome MembraneEndosomeMultivesicular Body Membrane |
| Alternative Antibody Names | Anti-Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9 antibodyAnti-V-Atpase Assembly Regulator Tmem9 antibodyAnti-Dermal Papilla-Derived Protein 4 antibodyAnti-Transmembrane Protein 9 antibodyAnti-Protein Tmem9 antibodyAnti-TMEM9 antibodyAnti-DERP4 antibodyAnti-TMEM9A antibodyAnti-HSPC186 antibodyAnti-PSEC0012 antibodyAnti-UNQ631 antibodyAnti-PRO1248 antibody |
Information sourced from Uniprot.org