| Host: | Rabbit |
| Applications: | WB/ICC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Meckelin (34-47 aa) is suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | R07-2A4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/ml |
| Dilution Range: | WB 1:500-1:1000 IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | TMEM67 |
| Gene ID: | 91147 |
| Uniprot ID: | MKS3_HUMAN |
| Immunogen Region: | 34-47 aa |
| Immunogen: | A synthetic peptide of human Meckelin |
| Tissue Specificity | Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord. |
| Function | Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A. In non-canonical Wnt signaling, it may act as ROR2 coreceptor. |
| Protein Name | Meckelin Meckel Syndrome Type 3 Protein Transmembrane Protein 67 |
| Database Links | Reactome: R-HSA-5620912 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endoplasmic Reticulum Membrane Cell Projection Cilium Cytoplasm Cytoskeleton Cilium Basal Body Localizes At The Transition Zone A Region Between The Basal Body And The Ciliary Axoneme |
| Alternative Antibody Names | Anti-Meckelin antibody Anti-Meckel Syndrome Type 3 Protein antibody Anti-Transmembrane Protein 67 antibody Anti-TMEM67 antibody Anti-MKS3 antibody |
Information sourced from Uniprot.org