| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CSC1-like protein 2 (627-677 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM63B |
| Gene ID: |
55362 |
| Uniprot ID: |
CSCL2_HUMAN |
| Immunogen Region: |
627-677 aa |
| Specificity: |
This antibody detects endogenous levels of TM63B at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TM63B at the amino acid range 627-677 |
| Function | Mechanosensitive cation channel with low conductance and high activation threshold. Essential for the baby's first breath and respiration throughout life. Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace. Osmosensitive cation channel preferentially activated by hypotonic stress. Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response. Required for the maintenance of OHC morphology, OHC survival and normal hearing. |
| Protein Name | Csc1-Like Protein 2Transmembrane Protein 63b |
| Cellular Localisation | Early Endosome MembraneMulti-Pass Membrane ProteinCell MembraneColocalizes With Cortical F-ActinLocalizes At Lamellar Body Membrane In Alveolar Type 2 Cells |
| Alternative Antibody Names | Anti-Csc1-Like Protein 2 antibodyAnti-Transmembrane Protein 63b antibodyAnti-TMEM63B antibodyAnti-C6orf110 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
